A Naturally Occurring Variant in Human TLR9, P99L, Is Associated with Loss of CpG Oligonucleotide Responsiveness

A Naturally Occurring Variant in Human TLR9, P99L, Is Associated with Loss of CpG Oligonucleotide Responsiveness

The innate immune system employs Toll-like receptors (TLRs) for the detection of invading microorganisms based on distinct molecular patterns. For example, TLR9 is activated by microbial DNA and also by short therapeutic CpG-containing oligonucleotides (CpG-ODN). TLR9 activation leads to the production of interferons and the priming of humoral adaptive immune responses. Unfortunately, the princ...

Coinfection Associated with Naturally Occurring Cryptosporidiosis in Broilers

A naturally occurring variant of Hsp90 that is associated with decanalization.

The heat shock protein Hsp90 has been the focus of many studies since it was suggested that it acts to mediate the buffering of phenotypic variation. Hsp90-mediated buffering may result in the accumulation of cryptic genetic variation that, when released either as a consequence of environmental or genetic stress, increases the evolvability of a population. Recent studies using laboratory-induce...

TIRAP Occurring Loss-of-Function Variant of MyD88 Adaptor-Like D96N Is a Naturally

A naturally occurring structural variant of human growth hormone.

A structural variant of human growth hormone was isolated from pituitary extracts. The newly recognized modification had a molecular weight of 20,000 when analyzed by electrophoresis in sodium dodecyl sulfate, whereas human growth hormone gave a value near 22,000. By isoelectric focusing the variant had a p1 of 5.85; human growth hormone had a value of 5.6. All extracts of 30 individual fresh f...